Course Overview

Domain
Food, Chemical and Biotechnology
Format
Short Course
Duration
2 days
Fee Subsidy
Up to 90% SF Funding

In the past 15 years, mammalian cell culture production processes have moved from the use of glass and stainless-steel bioreactors to disposable, single use bioreactor systems.

Thermo Fisher Scientific’s HyPerforma SUB systems, with scalable volumes ranging from 50L – 2000L is designed using traditional stainless-steel bioreactor principles to ensure optimal cell culture performance. This 2-day course will cover the fundamentals of Single Use Technology (SUT), sensors technology, assemblies and film material, mammalian cell expansion and scale up, the different modes of bioreactor operation and also installation, calibration and use of the HyPerforma SUB.

At the end of the course, participants will be fully equipped with the relevant skillsets to be part of the operations arm of the biomanufacturing industry.

Programme Partner

This course is a collaboration with Thermo Fisher Scientific.

ThermoFisherScientific

Who Should Attend

  • Biotechnologists and research scientists who are keen to explore the use of single use bioreactor technology for mammalian cell culture. Having a basic knowledge of bioprocess control would be helpful
Haja Mydin
"The training course is able to deliver information on bioprocess operation and the choices of equipment for intended applications. Trainers provided case studies for ease of understanding."
Anton Firdaus
QC Chemist, Novartis

What You Will Learn

Module Topics
Theory Fundamentals of Single Use Technology (SUT)
  • Introduction to SUT and its applications
  • Understand the major differences between SUT and conventional processes in terms of logistics, cost, turnaround time and operation
Sensors technology, assemblies and film material
  • Understand the function of each components associated with SUT
  • Assembly and operation of single use bioreactor systems
Cell expansion and scale up
  • Understand major culture scale up challenges and criteria in terms of media requirement, O2 supply, pH control and mixing
  • Determine operating condition at large scale culture using empirical data from lab and pilot scale
Batch, fed batch and perfusion culture
  • Understand different culture modes and their applications
  • Determine yield, productivity and cost analysis of bioprocess
Practical Bioreactor bag installation
  • Handling, fitting into holder, inflating and connection assembly
Integrity testing
  • Using integrity tester
Aseptic transfer
  • Test run using water, inoculation and sampling
Calibration of sensors
  • Dissolve oxygen, pH and pump calibration
Process control
  • Set-points, feeding and analysis of historical run data

Teaching Team

Adison Wong
Adison Wong

Associate Professor, Food, Chemical and Biotechnology, Singapore Institute of Technology

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Luo Weiwen
Luo Weiwen

BDC Staff Scientist (Upstream), Thermo Fisher Scientific

View profile

Schedule

Time Topic
8:30 am Registration and introduction
9:00 am Theory module 1: Fundamentals of Single Use Technology (SUT)
10:00 am Tea break and networking
11:00 am Theory module 2: Sensors technology, assemblies and film material
12:00 pm Lunch
1:30 pm Breakout groups (hands-on lab session)
Group 1: Aseptic connections, operation of pumps
Group 2: Single use bioreactor assembly and integrity testing
3:30 pm Tea break
4:00 pm Breakout groups (hands-on lab session)
Group 1: Single use bioreactor assembly and integrity testing
Group 2: Aseptic connections and operation of pumps
6:00 pm End of day
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Time Topic
8:30 am Recap of day 1 learning outcomes
9:00 am Theory module 3: Cell expansion and scale up
10:00 am Tea break and networking
11:00 am Theory module 4: Batch, fed-batch and perfusion culture
12:00 pm Lunch
1:30 pm Breakout groups (hands-on lab session)
Group 1: Calibration of sensors, process control and sampling
Group 2: Written assessment (short answer)
3:30 pm Tea break
4:00 pm Breakout groups (hands-on lab session)
Group 1: Assessment
Group 2: Calibration of sensors, process control and sampling
6:00 pm End of day
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Certificate and Assessment

A Certificate of Participation will be issued to participants who:

  • Attend 75% of the course
  • Undertake and pass non-credit bearing assessment during the course

Fee Structure

The full fee for this course is S$2,725.00

Category After SF Funding
Singapore Citizen (Below 40) S$817.50
Singapore Citizen (40 & Above) S$317.50
Singapore PR / LTVP+ Holder S$817.50
Non-Singapore Citizen S$2,725.00 (No Funding)


Note: All fees above include GST. GST applies to individuals and Singapore-registered companies.

Funding
Learn more about funding schemes available

Course Runs

There are no upcoming course runs at the moment.

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