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With Wenhai Zhuo

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Assistant Professor

Wenhai Zhuo

Assistant Professor
PhD in Medicine, National University of Singapore, Singapore
Cluster:
Health and Social Sciences
Email

SIT Appointments

  • Assistant Professor
    – Present

Education

  • PhD in Medicine
    National University of Singapore , Singapore
  • MMed
    Zhejiang University , China
  • MBBS
    Zhejiang University , China
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Research Interests

  • Targeting Ligamentum Flavum Hypertrophy for Spinal Stenosis Management
  • Enhancing Spinal Fusion Outcomes through Biologic Interventions
  • Sarcopenia and Spine Health: Therapeutic Interventions
  • Advancing Disc Regeneration Strategies for Degenerative Disc Disease

Current Projects

  • Spinal Sarcopenia in Older Adults: The Role of Senescent Progenitors and Regenerative Failure
    – Present
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Journal Papers

  • Zhuo, W. H., Hey, H. W. D., Lam, W. M. R., Chan, X. C., Lit, L. H., Chiong, Y. S., & Wong, H. K. (2024). Increased matrix metalloproteinase-2 in ligamentum flavum hypertrophy and the regulation of MMP-2/TIMPs by elastin-derived peptides. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 42(9), 2061–2071. https://doi.org/10.1002/jor.25841

  • Lam, W. M. R. & Zhuo, W. H., Yang, L., Tan, R., Lim, S. K., Hey, H. W. D., & Toh, W. S. (2024). Mesenchymal Stem Cell Exosomes Enhance Posterolateral Spinal Fusion in a Rat Model. Cells, 13(9), 761. https://doi.org/10.3390/cells13090761

  • Hey, H. W. D., Lam, W. M. R., Chan, C. X., Zhuo, W. H., Crombie, E. M., Tan, T. C., Chen, W. C., Cool, S., & Tsai, S. Y. (2022). Paraspinal myopathy-induced intervertebral disc degeneration and thoracolumbar kyphosis in TSC1mKO mice model-a preliminary study. The spine journal : official journal of the North American Spine Society, 22(3), 483–494. https://doi.org/10.1016/j.spinee.2021.09.003

  • Lam, WMR, Ren, XF, Tan, KC, Bhakoo, KK, Kumarsing, RA, Liu, L, Zhuo, WH, Wong, HK, Hey, HWD (2021-01-01). The Impact of Static Distraction for Disc Regeneration in a Rabbit Model—A Longitudinal MRI Study. 17th International Conference on Biomedical Engineering 79 : 101-107. https://doi.org/10.1007/978-3-030-62045-5_10

  • Hey, H. W. D. & Zhuo, W. H., Tan, Y. H. J., & Tan, J. H. (2020). Accuracy of freehand pedicle screws versus lateral mass screws in the subaxial cervical spine. Spine deformity, 8(5), 1049–1058. https://doi.org/10.1007/s43390-020-00119-z

  • Xue, D., Chen, Q., Chen, G., Zhuo, W., & Li, F. (2017). Posterior arthrodesis of C1-C3 for the stabilization of multiple unstable upper cervical fractures with spinal cord compromise: A case report and literature review. Medicine, 96(1), e5841. https://doi.org/10.1097/MD.0000000000005841

  • Zhang, H., Yang, Y., Wu, Y., Denslin, V., Koh, Y. W. J., Liu, L., Zhuo, W., Lam, W. M. R., Yu, Y., Hui, J. H. P., & Yang, Z. (2025). Unveiling the potential of MSC extracellular vesicles: MiR-122-5p enhancing chondrocyte regeneration in osteoarthritis via autophagy mechanism. Stem cell research & therapy, 16(1), 289. https://doi.org/10.1186/s13287-025-04412-4

  • Hey, H., Lam, W., Zhuo, W. et al. Site-specific myopathy differences between spine and limb muscles: a kyphotic TSC1mKO mice model study. Eur Spine J (2025). https://doi.org/10.1007/s00586-025-09656-5

Conferences

  • Does general exercise improve paraspinal myopathy, disc health and spinal alignment in sarcopenic TSC1mKO mice? ISSLS 2022, May 9-13 in Boston Marriott Copley Place (Oral Presentation)

  • Cellular and extracellular matrix modulation of ligamentum flavum hypertrophy induced by spinal destabilization. 49th ISSLS Annual Meeting 2023 Melbourne Australia 2023 May 1-5. (Special Poster)

  • M2 macrophage infiltration and modulation in hypertrophied ligamentum flavum. 49th ISSLS Annual Meeting 2023 Melbourne Australia 2023 May 1-5. (General Poster)

  • Elastin degradation products accelerate chondrogenesis and calcification of human ligamentum flavum-derived cells 50th ISSLS Annual Scientific Meeting, Milan, 27-31 May 2024. (General Poster)

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Teaching Modules

Diagnostic Radiography, BSc (Hons)

  • HSC1007 - Anatomy and Physiology 1
  • HSC1008 - Anatomy and Physiology 2
  • HSC4006 - Anatomical Dissection of Musculoskeletal System

Occupational Therapy, BSc (Hons)

  • HSC1007 - Anatomy and Physiology 1
  • HSC2008 - Pathophysiology and Pharmacology
  • HSC1008 - Anatomy and Physiology 2

Physiotherapy, BSc (Hons)

  • HSC1007 - Anatomy and Physiology 1
  • HSC2008 - Pathophysiology and Pharmacology
  • PTY4801 - Honours Thesis
  • HSC1008 - Anatomy and Physiology 2
  • HSC4006 - Anatomical Dissection of Musculoskeletal System

Radiation Therapy, BSc (Hons)

  • HSC1007 - Anatomy and Physiology 1
  • HSC2008 - Pathophysiology and Pharmacology
  • HSC1008 - Anatomy and Physiology 2

Dietetics and Nutrition, BSc (Hons)

  • HSC1007 - Anatomy and Physiology 1
  • HSC2008 - Pathophysiology and Pharmacology
  • HSC1008 - Anatomy and Physiology 2

Speech and Language Therapy, BSc (Hons)

  • HSC1007 - Anatomy and Physiology 1

Physiotherapy, BSc

  • PTY1016 - Foundation of Physiotherapy
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