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Associate Professor

Bernard LEUNG

Associate Professor
PhD (Immunology), University of Glasgow, UK., United Kingdom
Cluster:
Health and Social Sciences
Email

SIT Appointments

  • Associate Professor
    – Present

Education

  • PhD (Immunology)
    University of Glasgow, UK. , United Kingdom
  • BSc (Immunology)
    University of Glasgow, UK. , United Kingdom

Achievements

  • NUS Office of Life Sciences Young Investigator Award
  • Severe Acute Respiratory Syndrome Courage Star Award, Tan Tock Seng Hospital

Professional Memberships

  • American Association of Immunologists

Research Interests

Current Projects

  • Present

    The role of immune system in ageing

  • Present

    Role of immunomodulators in experimental inflammatory conditions

  • Role of inflammatory mediators in the development of autoimmunity/allergy
    Present

Journal Papers

  • Chong, M.S., L. Tay, N.H. Ismail, C.H. Tan, S. Yew, A. Yeo, R. Ye, B. Leung, and Y.Y. Ding. 2015. The case for stage-specific frailty interventions spanning community aging to cognitive impairment. J. Am. Med. Dir. Assoc. 16:1003.e13-e19

  • Lim, J.P., B.P. Leung, Y.Y. Ding, L. Tay, N.H. Ismail, A. Yeo, S. Yew, and M.S. Chong. 2015. Monocyte chemoattractant protein-1: a proinflammatory cytokine elevated in sarcopenic obesity. Clin. Interv. Aging 10:605

  • Tay, L., Y.Y. Ding, B.P. Leung, N.H. Ismail, A. Yeo, S. Yew, K.S. Tay, C.H. Tan, and M.S. Chong. 2015. Sex-specific differences in risk factors for sarcopenia amongst community-dwelling older adults. Age (Dordr). 37:121

  • Tan, R.S., B. Ho, B.P. Leung, and J.L. Ding. 2014. TLR Cross-talk Confers Specificity to Innate Immunity. Int. Rev. Immunol. 33:443

  • Goh, F.Y., K.L. Cook, N. Upton, L. Tao, L.C. Lah, B.P. Leung, and W.S. Wong. 2013. Receptor-interacting protein 2 gene silencing attenuates allergic airway inflammation. J. Immunol. 191:2691

  • Ting Tan, R.S., B. Lin, Q. Liu, L. Tucker-Kellogg, B. Ho, B.P. Leung, and J.L. Ding. 2013. The synergy in cytokine production through MyD88-TRIF pathways is coordinated with ERK phosphorylation in macrophages. Immunol. Cell Biol. 91:377

  • Goh, F.Y., N. Upton, S. Guan, C. Cheng, M.K. Shanmugam, G. Sethi, B.P. Leung, and W.S. Wong. 2012. Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-kappaB. Eur. J. Pharmacol. 679:109

  • Howe, H.S., K.O. Kong, B.Y. Thong, W.G. Law, F.L. Chia, T.Y. Lian, T.C. Lau, H.H. Chng, and B.P. Leung. 2012. Urine sVCAM-1 and sICAM-1 levels are elevated in lupus nephritis. Int. J. Rheum. Dis. 15:13

  • Lai, W.Q., F.L. Chia, and B.P. Leung. 2012. Sphingosine kinase and sphingosine 1-phosphate receptors: novel therapeutic targets of rheumatoid arthritis? Future Med. Chem. 4:727

  • Cheng, C., W.E. Ho, F.Y. Goh, S.P. Guan, L.R. Kong, W.Q. Lai, B.P. Leung, and W.S. Wong. 2011. Anti-malarial drug artesunate attenuates experimental allergic asthma via inhibition of the phosphoinositide 3-kinase/Akt pathway. PLoS One 6:e20932

  • Romero-Sanchez, C., H.K. Tsou, M.S. Jan, R.H. Wong, I.C. Chang, J. Londono, R. Valle-Onate, H.S. Howe, D. Yu, B.P. Leung, and J.C. Wei. 2011. Serum monocyte chemotactic protein-1 concentrations distinguish patients with ankylosing spondylitis from patients with mechanical lower back pain. J. Spinal Disord. Tech. 24:202

  • Crilly, A., S.E. Robertson, J.H. Reilly, J.A. Gracie, W.Q. Lai, B.P. Leung, P.F. Life, and I.B. McInnes. 2011. Phosphodiesterase 4 (PDE4) regulation of proinflammatory cytokine and chemokine release from rheumatoid synovial membrane. Ann. Rheum. Dis. 70:1130

  • Lai, W.Q., W.S. Wong, and B.P. Leung. 2011. Sphingosine kinase and sphingosine 1-phosphate in asthma. Biosci. Rep. 31:145

  • Peng, J., Q. Yuan, B. Lin, P. Panneerselvam, X. Wang, X.L. Luan, S.K. Lim, B.P. Leung, B. Ho, and J.L. Ding. 2010. SARM inhibits both TRIF- and MyD88-mediated AP-1 activation. Eur. J. Immunol. 40:1738

  • Bao, Z., S. Guan, C. Cheng, S. Wu, S.H. Wong, D.M. Kemeny, B.P. Leung, and W.S. Wong. 2009. A novel antiinflammatory role for andrographolide in asthma via inhibition of the nuclear factor-kappaB pathway. Am. J. Respir. Crit. Care Med. 179:657

  • Kong, K.O., A.W. Tan, B.Y. Thong, T.Y. Lian, Y.K. Cheng, C.L. Teh, E.T. Koh, H.H. Chng, W.G. Law, T.C. Lau, K.P. Leong, B.P. Leung, and H.S. Howe. 2009. Enhanced expression of interferon-inducible protein-10 correlates with disease activity and clinical manifestations in systemic lupus erythematosus. Clin. Exp. Immunol. 156:134

  • Lai, W-Q., A.W. Irwan, H.H. Goh, A.J. Melendez, I.B. McInnes, and B.P. Leung. 2009. Distinct roles of sphingosine kinase 1 and 2 in murine collagen-induced arthritis. J. Immunol. 183:2097